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Istradefylline forty mg/working day improved peak ranges and AUC of CYP3A4 substrates in scientific trials. This influence wasn't noticed with istradefylline 20 mg/day. Contemplate dose reduction of delicate CYP3A4 substrates.darifenacin will boost the amount or effect of triazolam by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Cauti